Cisplatin is a widely used chemotherapeutic drug showing high efficiency in the treatment of primary tumors such as ovarian, testicular and cervical cancers.The major drawback of cisplatin is tumor resistance either acquired or intrinsic.Many mechanisms are involved in the resistance, among them is the Nrf2 pathway which regulates glutathione relat
The objective of this article is to make a brief compilation of the physiology of the hypothalamic-pituitary-adrenal axis in order to understandthe role of the exogenous corticoids as therapeutic tools in innumerable pathologies, but when used inappropriately, it can produce Accessories important deleterious effects.The history of the corticoids be
This paper studies shrinkage estimation after the preliminary test for the parameters of exponential distribution based on record values.The optimal value of shrinkage Metal Detectors coefficients is also obtained based on the minimax regret criterion.The maximum likelihood, pre-test, and shrinkage estimators are compared using a simulation study.T
Bandung is one of the major cities in Indonesia.The lower middle class is greatly helped by public transportation.Angkot is transportation that is close to the people.However, public transportation services that are less organized can make people switch to using private transportation.This actually has a bad impact on traffic.Thus, there need to be